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Product Description

Product name: Ciprofloxacin HCl

CAS No.: 93107-08-5

Molecular formula: C17H18FN3O3.HCl

Molecular weight: 367.8

Melting point: >300 ºC

It is used for urogenital infections caused by sensitive bacteria, including simple and complicated urinary tract infections, bacterial prostatitis, Neisseria gonorrhoeae urethritis or cervicitis (including those caused by enzyme-producing strains). Respiratory tract infections, including acute onset of bronchial infections caused by sensitive gram-negative bacilli and lung infections. Gastrointestinal infections are caused by Shigella, Salmonella, enterotoxigenic Escherichia coli, Aeromonas hydrophila, and Vibrio parahaemolyticus. It can also treat typhoid bone and joint infections, skin and soft tissue infections, sepsis and other systemic infections.
 

Function

1 Urine alkalization drugs can reduce the solubility of the product in urine, leading to crystal urine and nephrotoxicity.
 

2 Antacids containing aluminum or magnesium can reduce the oral absorption of the product, and it is recommended to avoid combining them. If it cannot be avoided, it should be taken 2 hours before or 6 hours after taking the product.
 

3 When this product is used in combination with theophylline, it may be due to the competitive inhibition of the cytochrome P450 binding site, resulting in a significant reduction in liver elimination of theophylline, prolonged blood elimination half-life (t1/2β), increased blood concentration, and tea Symptoms of alkalosis, such as nausea, vomiting, tremor, restlessness, agitation, convulsions, heart palpitations, etc. Therefore, the blood concentration of theophylline should be measured and the dose adjusted when combined.
 

4 When cyclosporine is used in combination with this product, its blood concentration will increase, and the blood concentration of cyclosporine must be monitored and the dose adjusted.
 

5 When this product is used together with the anticoagulant warfarin, the latter's anticoagulant effect can be enhanced, and the patient's prothrombin time should be closely monitored when used in combination.
 

6 Probenecid can reduce the secretion of the product from the renal tubules by about 50%. When used in combination, it may cause toxicity due to the increased blood concentration of the product.
 

7 This product interferes with the metabolism of caffeine, resulting in reduced caffeine elimination, prolonged blood elimination half-life (t1/2β), and may cause central nervous system toxicity.
 

8 Didanosine (DDI) medicine can reduce the oral absorption of the product. Because the aluminum and magnesium contained in the preparation can be chelated with the product, it is not suitable for combined use.