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Product Description

Product name: Acyclovir

CAS No.: 59277-89-3

Molecular formula:C8H11N5O3

Molecular weight: 225.2

Melting point: 256-257°C

Acyclovir is a synthetic purine nucleoside analogue. It is mainly used for various infections caused by herpes simplex virus. It can be used for initial or recurrent skin, mucous membrane, external genital infections and HSV infections in people with immunodeficiency. It is the first choice for the treatment of HSV encephalitis, and it is better than arabinosine to reduce morbidity and mortality. It can also be used for herpes zoster, Epstein-Barr virus, and immunodeficiency patients with chickenpox and other infections. Topically applied to the skin only, acyclovir is less absorbed by the skin.

Function

1. Herpes simplex virus infection: Orally used for the initial and recurring cases of genital herpes virus infection; for recurrent cases, the product is used for prevention. Injections are used for people with immunodeficiency. Treatment of initial and recurrent mucosal skin infections and prevention of recurrent cases; also used in the treatment of herpes simplex encephalitis.
 

2. Herpes zoster: Orally used for the treatment of herpes with normal immune function and mild cases of immunodeficiency. The injection is used for the treatment of severe herpes patients with immunodeficiency.
 

3. Treatment of chickenpox in immunodeficiency patients.
 

4. Topically used for the initial treatment and recurrence of early genital herpes infection caused by herpes simplex virus and self-limited mucosal skin herpes simplex in immunodeficiency patients.
 

5. Use its sodium salt to treat acute retinal necrosis. Nucleotide antiviral drugs, used to treat:
① Herpes simplex keratitis;
②Herpes simplex;
③Herpes;
④ Treat acute retinal necrosis with its sodium salt. Mainly used for superficial and deep keratitis caused by herpes simplex virus and herpes zoster virus.

Application

1. Herpes simplex virus infection: It is used for the initial and recurring cases of genital herpes virus infection, and the product is taken orally for prevention of recurrent cases.
 

2. Herpes zoster: used for the treatment of patients with normal immune function and mild cases of immunodeficiency.
 

3. Treatment of chickenpox in immunodeficiency patients.
Acyclovir is catalyzed by the viral thymidine kinase (TK enzyme) and the kinase in the cell to generate acyclovir triphosphate in the infected cells, which inhibits the viral DNA polymerase. In addition, once acyclovir triphosphate is incorporated into the DNA that the virus is elongating, it will cause DNA synthesis to stop. Drug-resistant virus strains have been found clinically and experimentally, and the formation of drug resistance is related to the mutation of the viral thymidine kinase gene.