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Pharmaceutical Peptide Humanin Raw Material CAS 330936-69-1 with High Purity CAS NO.330936-69-1
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- Min.Order: 1 Gram
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Top quality(1-100)Gram
- Product Details
Keywords
- Humanin
- High Purity Humanin
- 330936-69-1
Quick Details
- ProName: Pharmaceutical Peptide Humanin Raw Mat...
- CasNo: 330936-69-1
- Molecular Formula: /
- Appearance: white powder
- Application: /
- DeliveryTime: 10-12 days
- PackAge: bag
- Port: shanghai
- ProductionCapacity: 10 Kilogram/Day
- Purity: 99%
- Storage: /
- Transportation: air
- LimitNum: 1 Gram
- DeliveryTime: 10-12 workdays
- Appearance: powder
- Origin: China
Superiority
Wuhan Senwayer century chemical Co..Ltd located in the predominant Wuhan City where is a traffic hinge of China, specialize in producing and developing pharmaceutical & its intermediates, Pesticide Intermediate, food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.
We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and other places.
Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
Details
| cas | 330936-69-1 |
| Name | Humanin |
| Synonyms | 1-24-Protein humanin (human) |
| MF | C119H204N34O32S2 |
| Purity | 99% |
| Application | Humanin (HN) is a cytoprotective 24 amino acid peptide which was originally isolated from a cDNA library constructed from nervous tissue of a patient with familial Alzheimer's disease (AD). Since then, it has been identified in different species such as mice, nematodes and rats (Niikura et al., 2004). The rat humanin homolog rattin (HNr) is a 38 amino acid peptide encoded and translated from an open reading frame (ORF) within the mitochondrial 16S ribosomal RNA (rRNA) gene (Caricasole et al., 2002; Paharkova et al., 2015). Several studies have demonstrated that HN is a potent pro-survival factor for neurons exposed to multiple cell stressors, such as Aβ oligomers and over-expression of familial AD-related genes serum deprivation , stroke and N-methyl-D-aspartate (NMDA)-induced excitotoxicity. HN and its derivatives have also proven to be beneficial in ameliorating cognitive impairment induced by Aβ, muscarinic receptor antagonists and aging in rodents. Moreover, HN and HNr were reported to prevent Aβ-induced spatial learning and memory impairments in rats by a mechanism involving changes in long-term potentiation , synaptic protein expression, dendritic branch number and spine density in the hippocampus . It has been reported that HN exerts its neuroprotective action from the extracellular space through binding to a trimeric IL-6-receptor-related receptor(s) on the cell surface involving the receptor for ciliary neurotrophic factor α (CNTFR-α), WSX-1 and glycoprotein 130 kDa (gp130) subunits and further modulation of tyrosin kinase, ERK1/2, AkT, STAT3 and JNK signaling cascades. HN has been ubiquitously detected in different adult tissues with high metabolic rate, including skeletal and cardiac muscle, cerebral cortex, hippocampus and liver both in humans and in rodents. The mechanisms regulating HN expression are not fully elucidated. It has been shown that HN levels decrease with age in human and mice plasma as well as in the rat hypothalamus Also, there is a sexual dimorphism in the expression of HN in rat anterior pituitary cells, suggesting that sex hormones are involved in the regulation of HN biosynthesis in this gland In the brain, HN has been widely localized both in neurons and glial cells, albeit the former only in pathological conditions Thus, glial cells have been suggested to be the main production sites of this peptide in the brain in physiological conditions However, astroglial HN expression and release and the regulation of such processes by ovarian hormones have not been studied so far. |