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Product Description

Product name: Risperidone

CAS No.: 106266-06-2

Molecular formula: C23H27FN4O2

Molecular weight: 410.48

Melting point: 170°C

This product is a derivative of benpropisoxazole, a new generation of antipsychotics. It has high affinity with 5-HT2 receptor and dopamine D2 receptor. This product can also bind to α1 receptors, has low affinity with H1 receptors and α2 receptors, and does not bind to cholinergic receptors. This product is a powerful D2 receptor antagonist, which can improve the positive symptoms of schizophrenia; but it causes less motor function inhibition and tonic fainting than classic antipsychotics. The balance of 5-HT and dopamine antagonistic effects on the central system can reduce the possibility of extrapyramidal side effects and extend its therapeutic effect to the negative and emotional symptoms of schizophrenia. This product is quickly and completely absorbed by oral administration, and its absorption is not affected by food. It reaches the peak blood concentration after 1 hour of medication, and the elimination half-life is about 3 hours. Most patients reach a steady state within 1 day. It is partially metabolized in the body to 9-hydroxyrisperidone, which has pharmacological activity and its elimination half-life is 24 hours. Most of this product is excreted from the kidneys. Elderly patients and patients with renal insufficiency have a slower clearance rate.

Application

Used to treat acute and chronic schizophrenia. Especially for positive and negative symptoms and the accompanying emotional symptoms (such as anxiety, depression, etc.) have a good effect. It can also reduce the emotional symptoms associated with schizophrenia. For patients with effective treatment in the acute phase, this product can continue to exert its clinical efficacy in the maintenance phase.