Wuhan Senwayer century chemical Co..Ltd located in the predominant Wuhan City where is a traffic hinge of China, specialize in producing and developing pharmaceutical & its intermediates, Pesticide Intermediate, food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.

We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and other places.

Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.

We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc. With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Product Introduction

CAS:50-50-0

MF: C25H28O3

MW:376.5

EINECS NO.:200-043-7

Melting Point:191-198 °C(lit.)

Boiling Point:465.03°C (rough estimate)

Density:1.0493 (rough estimate)

Product Description

Estradiolbenzoate is a synthetic ester, especially 3-benzoyl ester, natural estrogen, estradiol. Estrogens guides the development of female genes during embryonic development and puberty. Estradiol is the main female hormone secreted by the ovaries before menopause. Estradiolbenzoat Chemicalbooke is an estradiol analogue that contains a benzyl ester at the C-3 position and is often used in combination with progesterone to induce estrus in livestock. The compound binds to human and mouse estrogen receptor alpha (ERα), and chicken ER, with IC50 values ranging from 22-28 nM. This reflects a 6-10 fold reduction in affinity compared to estradiol.

Function

The effects of daily injections of 5 microgram estradiol benzoate (EB) on the patterns of food and ethanol consumption were studied in ovarectomized rats given free access to food, a 10% ethanol solution, and water. EB led to an immediate, but transient, suppression of both food and ethanol intake. The time course and magnitude of these effects were virtually identical. While the decrease in total food intake was achieved by a permanent decrease in the duration of eating bouts, the decline in total ethanol consumption apparently resulted from decreased rates of licking within bouts. Gradual increases in the frequency of eating and ethanol-drinking bouts allowed total food and ethanol intake to return to baseline within three weeks of the first injection. Total water intake rose three-fold during EB administration and this was due to increases in both the duration and frequency of drinking bouts. The similarity in effects induced by EB on the patterns of food and ethanol intake were discussed in terms of ethanol's caloric property.