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Product Description

Product name: CHOLESTYRAMINE RESIN

CAS No.: 11041-12-6

Molecular formula: C27H47N

Molecular weight: 385.66878

Melting point: /

Cholestyramine (cholestyramine) is the most important kind of resin drugs with lipid-lowering effect. The effect of the drug in reducing cholesterol and reducing the morbidity and mortality of coronary heart disease has been confirmed by long-term large-scale clinical practice Chemicalbook. However, due to certain side effects, and the lipid-lowering effect is not as good as "statin" drugs, it has been rarely used clinically in recent years, but when combined with other types of lipid-lowering drugs, it can improve the efficacy and reduce side effects, and has better Clinical significance.

Function

This product is a strongly basic quaternary amine anion exchange resin, which is the drug with the strongest cholesterol-lowering effect. After oral administration, this product combines with bile acid in the intestine, and the resulting coordination compound is not absorbed, but excreted with feces, thereby blocking the hepatic and enteric circulation of bile acid and reducing the amount of bile acid in the liver. Cholesterol in the blood is more converted into bile acid, which reduces the cholesterol content in the blood. At the same time, bile acid is a necessary substance for the absorption of cholesterol in the intestine. The bile acid is combined with this product in the intestine to reduce the absorption of cholesterol in food and also play a role in lowering cholesterol.

Application

Carbopol is a commonly used excipient in pharmaceutical preparations. Compared with cholestyramine, it has a longer gastric residence time, and the drug can be evenly distributed throughout the stomach after taking it. This finding indicates that cholestyramine may be developed into a mucosal drug release formulation targeting the gastric mucosa. For example, it can be combined with antibiotics to make a membrane adhesive sheet for eradicating Chemicalbook Helicobacter pylori infection. Cholestyramine is made into microcapsules that can release drugs floating in the stomach. This kind of microcapsules can greatly prolong the residence time in the stomach through mucosal adsorption. This preparation is very helpful in the treatment of gastric ulcers caused by Helicobacter pylori. Therefore, it can be expected that with in-depth research on this subject, cholestyramine may be used in pharmaceutical preparations for the treatment of gastric ulcer.